Organic Acid Testing - Urine

Organic acid testing help create your individualised supplement program by targeting the function of metabolic processes in the body. 

It’s a bit like when you put your car onto the road and your mechanic analyses the exhaust gases. You can learn a lot about how well your engine is running. 

Organix® Comprehensive nutritional test can assess the following issues:​

  • Fatigue ​

  • Depression

  • Weight gain

  • Stress

  • Digestive issues

  • Toxicity

How can this test help me?

  • Fat burning

    • Everyone wants to be a fat burning beast, right? This test will reveal shows how well your beta-oxidation is working. 

  • Blood sugar stabilization

    • This test was originally developed to help chronically ill patients, many of whom were pre-diabetic. The strange thing is those people have a lot in common with some athletes because (I suspect) of all the sugary sports supplements. This test can show you how well you’re burning carbs.

  • Energy production

    • You might have heard of the Citric Acid or Krebs cycle in biology. It’s the process by which you convert food and air into energy. Each step of the process requires certain enzymes and nutrients to be in place, and when they’re lacking it shows up on this test. Once you know, it’s not hard to fix with supplements like CoQ10 for example.

  • Methylation

    • Methylation is the way in which our body turns off the genes that are the blueprint which defines us. It’s also critically important for detoxification. If you’ve done a 23andme saliva test and worried about the MTHFR mutation, do this test as it will help you understand how well your methylation is actually working.

    • One of the most sensitive markers for vitamin B12 deficiency is methylmalonic acid an organic acid that’s on this test.

  • Toxins and detoxification

    • Everybody is exposed to toxins, it’s in the food we eat, the air we breathe. That’s why we have a liver, but sadly it’s becoming increasingly overburdened. 2-methylhippurate is an organic acid is on this test, it’s a breakdown product of xylene from paints, varnishes, carpet. New car smell. The scary thing is that it’s not on this test to detect accidental exposure, it’s on because everyone is exposed to xylene and therefore it’s a reliable marker of liver function.

    • Find out how much your liver’s struggling, so you can support the liver with extra nutrients.

  • Oxidative stress/antioxidants

    • This is a very difficult area, but really common. Some would argue that oxidative stress plays a role in Alzheimer's disease and aging.

    • In healthy people the role of oxidative stress is far from clear but there is no doubt that many doctors believe a vegetable based diet rich in antioxidants is useful.

    • Athletes create more oxidative stress through increased energy production.

  • Neurotransmitter turnover

    • This test measures the metabolic ashes of dopamine, serotonin and adrenaline. Usually the solution to problems found is stress reduction and lifestyle modification but in many cases amino acid therapy can be extremely helpful for insomnia, anxiety, depression and addiction.

    • This is not a direct test for neurotransmitters. 

  • Intestinal bacterial overgrowth

    • Certain bad bacteria in our gut, specially in the small intestine produce chemicals that can be measured on this test. It’s a crude test for SIBO. If you have an overgrowth of these bacteria then it’ll show up as bloating and on this test.

    • Sometimes you can crowd out these bacteria with probiotics but sometimes a short killing phase works better.

What is being tested?

First morning urine sample is analysed for organic acids which are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. Several of the biomarkers are markers of intestinal bacterial or yeast overgrowth.

The Organix® Comprehensive nutritional test profile provides vital patient information from a single urine specimen. This organic acids nutritional test is valuable for determining:

  • Functional vitamin and mineral status

  • Amino acid insufficiencies like carnitine and NAC

  • Oxidative damage and antioxidant need

  • Phase I & Phase II detoxification capacity

  • Functional B-complex vitamin need

  • Neurotransmitter metabolites

  • Mitochondrial energy production

  • Methylation sufficiency

  • Lipoic acid and CoQ10 status

  • Markers for bacterial and yeast overgrowth

References/More information:

Genova Diagnostics click here

Evaluation of a functional medicine approach to treating fatigue, stress and digestive issues in women; Cutshall, S., Bergstrom, L., & Kalish, D. Complementary Therapies in Clinical Practice 23 (2016) 75-81 

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Naturopath Hastings